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Bioactivity and chemistry of the genus Hortonia

Ratnayake, Rukmal; Bandara, B M; Wijesundara, Siril; MacLeod, John; Simmonds, Peta; Karunaratne, Veranja

Description

The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profiles and mosquito larvicidal and antifungal activities; protein analysis of the leaves of the three species of Hortonia showed identical peaks and bands. The two major metabolites...[Show more]

dc.contributor.authorRatnayake, Rukmal
dc.contributor.authorBandara, B M
dc.contributor.authorWijesundara, Siril
dc.contributor.authorMacLeod, John
dc.contributor.authorSimmonds, Peta
dc.contributor.authorKarunaratne, Veranja
dc.date.accessioned2015-12-10T22:26:33Z
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/1885/53823
dc.description.abstractThe dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profiles and mosquito larvicidal and antifungal activities; protein analysis of the leaves of the three species of Hortonia showed identical peaks and bands. The two major metabolites (4S)-4-methyl-2-(11-dodecynyl)-2-butenolide (2) and (4S)-4-methyl-2-(11-dodecenyl)-2-butenolide (3), which were previously reported from all three plants, showed potent larvicidal activities. Compound 2 was excessively high in the extracts of the stem bark and the roots of all three species amounting to approximately 38 and 60%, respectively. A minor new butenolide (4), (4S)-4-methyl-2-((2R)-hydroxy-11-dodecenyl)-2-butenolide, with much reduced larvicidal activity and ishwarane (1), which showed antifungal activity, were also isolated from all three plants. Treatment of compound 2 with H2/Pd-C afforded the completely reduced compound 5, which showed no larvicidal activity, indicating that unsaturation in both 2 and 3 is necessary for their bioactivity. The foregoing evidence showed that there are major similarities between the three species of Hortonia.
dc.publisherTaylor & Francis Group
dc.sourceNatural Product Research
dc.subjectKeywords: 4 methyl 2 (11 dodecenyl) 2 butenolide; 4 methyl 2 (11 dodecynyl) 2 butenolide; 4 methyl 2 (hydroxy 11 dodecenyl) 2 butenolide; butenolide; dichloromethane; Hortonia angustifolia extract; Hortonia floribunda extract; Hortonia ovalifolia extract; ishwarane Antifungal activity; Dichloromethane extracts; HPLC analysis; Mosquito larvicidal activity; New butenolide; Protein analysis; Qenus Hortonia; Similarity between species
dc.titleBioactivity and chemistry of the genus Hortonia
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume22
dc.date.issued2008
local.identifier.absfor030502 - Natural Products Chemistry
local.identifier.ariespublicationu4005981xPUB284
local.type.statusPublished Version
local.contributor.affiliationRatnayake, Rukmal, University of Peradeniya
local.contributor.affiliationBandara, B M, University of Peradeniya
local.contributor.affiliationWijesundara, Siril, Royal Botanic Gardens, Sri Lanka
local.contributor.affiliationMacLeod, John, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSimmonds, Peta, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKarunaratne, Veranja, University of Peradeniya
local.description.embargo2037-12-31
local.bibliographicCitation.issue16
local.bibliographicCitation.startpage1393
local.bibliographicCitation.lastpage1402
local.identifier.doi10.1080/14786410701722433
dc.date.updated2016-02-24T10:22:51Z
local.identifier.scopusID2-s2.0-57049176584
local.identifier.thomsonID000261337000002
CollectionsANU Research Publications

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