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Prevalence of CARD15/NOD2 mutations in Caucasian healthy people

Hugot, Jean-Pierre; Isabelle, Zaccaria; Cavanaugh, Juleen; Yang, Huiying; Severine, Vermeire; Maarit, Lappalainen; Schreiber, Stefan; Annese, Vito; Jewell, Derek P.; Fowler, Elizabeth V; Brant, Steven; Silverberg, Mark S; Cho, Judy H; Rioux, John D.; Satsangi, Jack; Parkes, Miles


BACKGROUND: Crohn's disease (CD) has been associated with CARD15/NOD2 mutations in Caucasians. The R702W, G908R, and 1007fs mutations represent 82% of the mutated chromosomes. The relative risk of developing CD in homozygous or compound heterozygous people has been estimated as between 10 and 40 times that of the general population. This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels. SUBJECTS AND METHODS: The...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: American Journal of Gastroenterology
DOI: 10.1111/j.1572-0241.2007.01149.x


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