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Insights into Processing and Cyclization Events Associated with Biosynthesis of the Cyclic Peptide Kalata B1

Conlan, Brendon; Colgrave, Michelle L; Gillon, Amanda D; Guarino, Rosemary; Craik, David J; Anderson, Marilyn


Plant cyclotides are the largest family of gene-encoded cyclic proteins. They act as host defense molecules to protect plants and are promising candidates as insecticidal and nematocidal agents in agriculture. For this promise to be realized a greater understanding of the post-translational processing of these proteins is needed. Cyclotides are cleaved from precursor proteins with subsequent ligation of the N and C termini to form a continuous peptide backbone. This cyclization step is...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M112.347823


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