Conlan, Brendon; Colgrave, Michelle L; Gillon, Amanda D; Guarino, Rosemary; Craik, David J; Anderson, Marilyn
Plant cyclotides are the largest family of gene-encoded cyclic proteins. They act as host defense molecules to protect plants and are promising candidates as insecticidal and nematocidal agents in agriculture. For this promise to be realized a greater understanding of the post-translational processing of these proteins is needed. Cyclotides are cleaved from precursor proteins with subsequent ligation of the N and C termini to form a continuous peptide backbone. This cyclization step is...[Show more]
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