Liang, Simon; Pinkevych, Mykola; Khachigian, Levon M; Parish, Christopher; Davenport, Miles P.; Chong, Beng
Drug-induced immune thrombocytopenia (DITP) is an adverse drug effect mediated by drug-dependent antibodies. Intravenous immunoglobulin (IVIG) is frequently used to treat DITP and primary immune thrombocytopenia (ITP). Despite IVIG's proven beneficial effects in ITP, its efficacy in DITP is unclear. We have established a nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of DITP in which human platelets survive for more than 24 hours, allowing platelet clearance by...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.