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ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice

Liu, Xin; Dobbie, Michael; Tunningley, Robert; Whittle, Belinda; Zhang, Yafei; Ittner, Lars M; Gotz, Jurgen


Modifier screening is a powerful genetic tool. While not widely used in the vertebrate system, we applied these tools to transgenic mouse strains that recapitulate key aspects of Alzheimer's disease (AD), such as tau-expressing mice. These are characterized by a robust pathology including both motor and memory impairment. The phenotype can be modulated by ENU mutagenesis, which results in novel mutant mouse strains and allows identifying the underlying gene/mutation. Here we discuss this...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Biomedicine and Biotechnology
DOI: 10.1155/2011/130947


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