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Reduced Switching In SCID B cells Is associated with altered somatic mutation of recombined S regions

Cook, Adam; Oganesian, Liana; Harumal, Pearly; Basten, Antony; Brink, Robert; Jolly, Christopher J


Deoxyribonucleic acid double-stranded breaks act as intermediates in Ig V(D)J recombination and probably perform a similar function in class switch recombination between IgH C genes. In SCID mice, V(D)J recombination is blocked because the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein is defective. We show in this study that switching to all isotypes examined was detectable when the SCID mutation was introduced into anti-hen egg lysozyme transgenic B cells capable of...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Immunology


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