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Application of a double Mannich reaction using bis(aminol) ethers in the synthesis of AE ring analogues of methyl lycaconitine

Brocke, Constanze; Brimble, Margaret A; Lin, Diana S-H; McLeod, Malcolm


An efficient method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes is reported via double Mannich reaction of cyclic ketoesters with bis(aminol) ethers. This method is applied to the synthesis of AE ring analogues of methyl

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Synlett
DOI: 10.1055/s-2004-831340


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