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Synthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore

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Barker, David; Brimble, Margaret A; McLeod, Malcolm

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The synthesis of several A and AE ring analogues of the alkaloid methyllycaconitine is reported. The key 2-(2″-methylsuccinimido)benzoate ester pharmacophore is introduced using an efficient two step procedure. Esterification of the alcohol precursors w

dc.contributor.authorBarker, David
dc.contributor.authorBrimble, Margaret A
dc.contributor.authorMcLeod, Malcolm
dc.date.accessioned2015-12-10T22:24:04Z
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/1885/53091
dc.description.abstractThe synthesis of several A and AE ring analogues of the alkaloid methyllycaconitine is reported. The key 2-(2″-methylsuccinimido)benzoate ester pharmacophore is introduced using an efficient two step procedure. Esterification of the alcohol precursors w
dc.publisherElsevier
dc.sourceTetrahedron
dc.subjectKeywords: 2 (2'' methylsuccinimido)benzoate; acid anhydride; alkaloid derivative; anthranilic acid; benzoic acid derivative; methyllycaconitine; sodium borohydride; trifluoroacetic acid; unclassified drug; Aconitum; article; drug structure; drug synthesis; esterifi Alkaloids; Anthranilate esters; Methyllycaconitine; Nicotinic acetylcholine receptors
dc.titleSynthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume60
dc.date.issued2004
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationu4005981xPUB264
local.type.statusPublished Version
local.contributor.affiliationBarker, David, University of Sydney
local.contributor.affiliationBrimble, Margaret A, University of Auckland
local.contributor.affiliationMcLeod, Malcolm, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue28
local.bibliographicCitation.startpage5953
local.bibliographicCitation.lastpage5963
local.identifier.doi10.1016/j.tet.2004.05.024
dc.date.updated2015-12-09T09:13:37Z
local.identifier.scopusID2-s2.0-2942750323
CollectionsANU Research Publications

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