Sedger, Lisa; Katewa, Arna; Pettersen, Ann; Osvath, Sarah; Farrell, Geoffrey; Stewart, Graeme; Bendall, Linda; Alexander, Stephen
To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we generated mice defective in both molecules. B6.GT mice develop severe polyclonal lymphoproliferative disease because of accumulating CD3+CD4- CD8-B220+ T cells, CD4+ and CD8+ T cells, and follicular B cells, and mice die prematurely from extreme lymphocytosis, thrombocytopenia, and hemorrhage. Accumulating lymphocytes...[Show more]
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