Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice
-
Altmetric Citations
Sedger, Lisa; Katewa, Arna; Pettersen, Ann; Osvath, Sarah; Farrell, Geoffrey; Stewart, Graeme; Bendall, Linda; Alexander, Stephen
Description
To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we generated mice defective in both molecules. B6.GT mice develop severe polyclonal lymphoproliferative disease because of accumulating CD3+CD4- CD8-B220+ T cells, CD4+ and CD8+ T cells, and follicular B cells, and mice die prematurely from extreme lymphocytosis, thrombocytopenia, and hemorrhage. Accumulating lymphocytes...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/53065 |
Source: | Blood |
DOI: | 10.1182/blood-2009-11-255497 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Sedger_Extreme_lymphoproliferative_2010.pdf | 1.12 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 19 May 2020/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator