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Substrate control in the asymmetric aminohydroxylation of monosubstituted alkenes: the enantioselective synthesis of GABOB and homoserine derivatives

Harding, Michael; Bodkin, Jennifer A; Hutton, Craig A; McLeod, Malcolm

Description

The 4-nitrophenyl ether is an efficient directing group in the asymmetric aminohydroxylation reaction of but-3-en-1-ol derivatives. Either regioisomeric product can be obtained with useful levels of enantioselectivity, allowing for the short enantioselective synthesis of GABOB and homoserine derivatives.

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/52991
Source: Synlett
DOI: 10.1055/s-2005-918939

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