Substrate control in the asymmetric aminohydroxylation of monosubstituted alkenes: the enantioselective synthesis of GABOB and homoserine derivatives

Abstract

The 4-nitrophenyl ether is an efficient directing group in the asymmetric aminohydroxylation reaction of but-3-en-1-ol derivatives. Either regioisomeric product can be obtained with useful levels of enantioselectivity, allowing for the short enantioselective synthesis of GABOB and homoserine derivatives.