Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse
Curtin, John A; Quint, Elizabeth; Tsipouri, Vicky; Arkell, Ruth; Cattanach, Bruce; Copp, Andrew J; Henderson, Deborah J; Spurr, Nigel; Stanier, Philip L; Fisher, Elizabeth M; Nolan, Patrick; Steel, Karen P; Brown, Steve D M; Gray, Ian C; Murdoch, Jennifer N
We identified two novel mouse mutants with abnormal head-shaking behavior and neural tube defects during the course of independent ENU mutagenesis experiments. The heterozygous and homozygous mutants exhibit defects in the orientation of sensory hair cells in the organ of Corti, indicating a defect in planar cell polarity. The homozygous mutants exhibit severe neural tube defects as a result of failure to initiate neural tube closure. We show that these mutants, spin cycle and crash, carry...[Show more]
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