Barker, David; Lin, Diana S-H; Carland, Jane E; Chu, Cindy P-Y; Chebib, Mary; Brimble, Margaret A; Savage, G Paul; McLeod, Malcolm
Bicyclic analogues of methyllycaconitine (MLA), such as 12, have been synthesised that incorporate the C1-OMe substituent present in the natural product. Electrophysiology experiments using Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) were conducted on these analogues and a related tricyclic analogue 2. The most potent compound, 2, was an antagonist at all receptors studied but displayed different antagonist effects at each receptor subtype. This study more clearly...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.