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New Semidominant Mutations that affect Mouse Development

Bogani, Debora; Warr, Nick; Elms, Paul; Davies, Jennifer; Tymowska-Lalanne, Zuzanna; Goldsworthy, Michelle; Cox, Roger D; Keays, David A; Flint, Jonathan; Wilson, Valerie; Nolan, Patrick; Arkell, Ruth

Description

Dominantly acting mutations that produce visible phenotypes are frequently recovered, either during routine maintenance of colonies or from mutagenesis experiments. We have studied 12 dominant mouse mutations that cause a tail dysmorphology, a coat spotting phenotype, or a combination of these. The majority of these mutations act in a semidominant manner with the homozygous state associated with embryonic lethality and a visible phenotype at or before midgestation. The homozygous phenotypes...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/52936
Source: Genesis
DOI: 10.1002/gene.20071

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