New Semidominant Mutations that affect Mouse Development
Bogani, Debora; Warr, Nick; Elms, Paul; Davies, Jennifer; Tymowska-Lalanne, Zuzanna; Goldsworthy, Michelle; Cox, Roger D; Keays, David A; Flint, Jonathan; Wilson, Valerie; Nolan, Patrick; Arkell, Ruth
Dominantly acting mutations that produce visible phenotypes are frequently recovered, either during routine maintenance of colonies or from mutagenesis experiments. We have studied 12 dominant mouse mutations that cause a tail dysmorphology, a coat spotting phenotype, or a combination of these. The majority of these mutations act in a semidominant manner with the homozygous state associated with embryonic lethality and a visible phenotype at or before midgestation. The homozygous phenotypes...[Show more]
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