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Double-Mannich annulation of cyclic ketones using N,N-bis(ethoxymethyl)alkylamine reagents

Halliday, Jill I; Chebib, Mary; Turner, Peter; McLeod, Malcolm


N,N-Bis(ethoxymethyl)alkylamines function as effective reagents in the double-Mannich annulation of cyclic ketone substrates, providing efficient access to a series of azabicyclic ketones. These ring systems are a useful scaffold for the four-step synthesis of novel constrained homocholine analogues.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Organic Letters
DOI: 10.1021/ol061242s


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