Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length
In Saccharomyces cerevisiae, DNA replication stress activates the replication checkpoint, which slows S-phase progression, stabilizes slowed or stalled replication forks, and relieves inhibition of the ribonucleotide reductase (RNR) complex. To identify novel genes that promote cellular viability after replication stress, the S. cerevisiae non-essential haploid gene deletion set (4812 strains) was screened for sensitivity to the RNR inhibitor hydroxyurea (HU). Strains bearing deletions in...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Cell Science|
|01_Woolstencroft_Ccr4_contributes_to_tolerance_2006.pdf||1.74 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.