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Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

Woolstencroft, Robert N; Beilharz, Traude H; Cook, Michael A; Preiss, Thomas; Durocher, Daniel; Tyers, Mike

Description

In Saccharomyces cerevisiae, DNA replication stress activates the replication checkpoint, which slows S-phase progression, stabilizes slowed or stalled replication forks, and relieves inhibition of the ribonucleotide reductase (RNR) complex. To identify novel genes that promote cellular viability after replication stress, the S. cerevisiae non-essential haploid gene deletion set (4812 strains) was screened for sensitivity to the RNR inhibitor hydroxyurea (HU). Strains bearing deletions in...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/52582
Source: Journal of Cell Science
DOI: 10.1242/jcs.03221

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