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Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes

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Hadler, Kieran S; Tanifum, Eric A; Yip, Sylvia; Mitic, Natasa; Guddat, Luke; Jackson, Colin; Gahan, Lawrence; Nguyen, Thi Kelly; Carr, Paul D; Ollis, David; Hengge, Alvan C; Larrabee, James A; Schenk, Gerhard

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The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of

dc.contributor.authorHadler, Kieran S
dc.contributor.authorTanifum, Eric A
dc.contributor.authorYip, Sylvia
dc.contributor.authorMitic, Natasa
dc.contributor.authorGuddat, Luke
dc.contributor.authorJackson, Colin
dc.contributor.authorGahan, Lawrence
dc.contributor.authorNguyen, Thi Kelly
dc.contributor.authorCarr, Paul D
dc.contributor.authorOllis, David
dc.contributor.authorHengge, Alvan C
dc.contributor.authorLarrabee, James A
dc.contributor.authorSchenk, Gerhard
dc.date.accessioned2015-12-10T22:22:14Z
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/1885/52581
dc.description.abstractThe glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of
dc.publisherAmerican Chemical Society
dc.sourceJournal of the American Chemical Society
dc.subjectKeywords: Binding energy; Binding sites; Biochemistry; Coordination reactions; Crystal structure; Electrolysis; Enzyme activity; Enzymes; Hydrogen; Hydrogen bonds; Hydrolysis; Ions; Laws and legislation; Metal ions; Metals; Network protocols; Nucleophiles; Quantum
dc.titleSubstrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume130
dc.date.issued2008
local.identifier.absfor030403 - Characterisation of Biological Macromolecules
local.identifier.ariespublicationu4005981xPUB250
local.type.statusPublished Version
local.contributor.affiliationHadler, Kieran S, University of Queensland
local.contributor.affiliationTanifum, Eric A, Utah State University
local.contributor.affiliationYip, Sylvia, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationMitic, Natasa, University of Queensland
local.contributor.affiliationGuddat, Luke, University of Queensland
local.contributor.affiliationJackson, Colin, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGahan, Lawrence, University of Queensland
local.contributor.affiliationNguyen, Thi Kelly, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCarr, Paul D, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOllis, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationHengge, Alvan C, Utah State University
local.contributor.affiliationLarrabee, James A, Middlebury College
local.contributor.affiliationSchenk, Gerhard, University of Queensland
local.description.embargo2037-12-31
local.bibliographicCitation.issue43
local.bibliographicCitation.startpage14129
local.bibliographicCitation.lastpage14138
local.identifier.doi10.1021/ja803346w
dc.date.updated2016-02-24T10:22:49Z
local.identifier.scopusID2-s2.0-54849416353
local.identifier.thomsonID000260301700048
CollectionsANU Research Publications

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