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Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes

Hadler, Kieran S; Tanifum, Eric A; Yip, Sylvia; Mitic, Natasa; Guddat, Luke; Jackson, Colin; Gahan, Lawrence; Nguyen, Thi Kelly; Carr, Paul D; Ollis, David; Hengge, Alvan C; Larrabee, James A; Schenk, Gerhard


The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja803346w


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