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Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues

Garrick, David; Sharpe, Jackie A; Arkell, Ruth; Dobbie, Lorraine; Smith, Andrew J H; Wood, William G; Higgs, Douglas R; Gibbons, Richard J

Description

ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic disease associated with defects in such proteins. To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cell...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/52566
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.0020058

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