Ybot-Gonzalez, Patricia; Gaston-Massuet, Carles; Girdler, Gemma; Klingensmith, John; Arkell, Ruth; Greene, Nicholas D E; Copp, Andrew J
Dorsolateral bending of the neural plate, an undifferentiated pseudostratified epithelium, is essential for neural tube closure in the mouse spinal region. If dorsolateral bending fails, spina bifida results. In the present study, we investigated the molecular signals that regulate the formation of dorsolateral hinge points (DLHPs). We show that Bmp2 expression correlates with upper spinal neurulation (in which DLHPs are absent); that Bmp2-null embryos exhibit premature, exaggerated DLHPs; and...[Show more]
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