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A Network of Multiple Regulatory Layers Shapes Gene Expression in Fission Yeast

Lackner, Daniel H; Beilharz, Traude H; Marguerat, Samuel; Mata, Juan; Watt, Stephen; Schubert, Falk; Preiss, Thomas; Bahler, Jurg


Gene expression is controlled at multiple layers, and cells may integrate different regulatory steps for coherent production of proper protein levels. We applied various microarray-based approaches to determine key gene-expression intermediates in exponentially growing fission yeast, providing genome-wide data for translational profiles, mRNA steady-state levels, polyadenylation profiles, start-codon sequence context, mRNA half-lives, and RNA polymerase II occupancy. We uncovered widespread and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Molecular Cell
DOI: 10.1016/j.molcel.2007.03.002


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