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Does melatonin help save dopaminergic cells in MPTP-treated mice?

Ma, Jeannine; Shaw, Victoria E; Mitrofanis, John


This study explores whether melatonin neuroprotects dopaminergic cells of the substantia nigra pars compacta (SNc) from degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice (well-known animal model of Parkinson disease). BALB/c albino mice were divided into four experimental groups. In each, mice received three series (over a 24-h period) of two intraperitoneal injections (1 h apart) in different combinations. The different groups and their combinations of injections...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Parkinsonism and Related Disorders
DOI: 10.1016/j.parkreldis.2008.07.008


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