Norris, Nicole; Bingham, Richard; Harris , Gemma; Speakman, Adrian; Jones, Richard P.O.; Leech, Andrew; Tukenburg, Johan P.; Potts, Jennifer R.
Bacterial fibronectin-binding proteins (FnBPs) contain a large intrinsically disordered region (IDR) that mediates adhesion of bacteria to host tissues, and invasion of host cells, through binding to fibronectin (Fn). These FnBP IDRs consist of Fn-binding repeats (FnBRs) that form a highly extended tandem β-zipper interaction on binding to the N-terminal domain of Fn. Several FnBR residues are highly conserved across bacterial species, and here we investigate their contribution to the...[Show more]
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