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Structural and functional analysis of the tandem β-zipper interaction of a streptococcal protein with human fibronectin

Norris, Nicole; Bingham, Richard; Harris , Gemma; Speakman, Adrian; Jones, Richard P.O.; Leech, Andrew; Tukenburg, Johan P.; Potts, Jennifer R.


Bacterial fibronectin-binding proteins (FnBPs) contain a large intrinsically disordered region (IDR) that mediates adhesion of bacteria to host tissues, and invasion of host cells, through binding to fibronectin (Fn). These FnBP IDRs consist of Fn-binding repeats (FnBRs) that form a highly extended tandem β-zipper interaction on binding to the N-terminal domain of Fn. Several FnBR residues are highly conserved across bacterial species, and here we investigate their contribution to the...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M111.276592


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