Improved Poststorage Cardiac Function by Poly (ADP-ribose) Polymerase Inhibition: Role of Phosphatidylinositol 3-Kinase Akt Pathway
BACKGROUND. Inhibition of poly(ADP-ribose) polymerase 1 (PARP) has been shown to be effective in minimizing cardiac ischemia reperfusion injury. We investigated the cardioprotective effect of the PARP inhibitor, INO-1153, in isolated working rat hearts after 6 hr of hypothermic storage in Celsior. METHODS. Hearts were treated with 1 μM INO-1153 before hypothermic storage, at cardioplegia and storage or after hypothermic storage. Hearts not exposed to INO-1153 served as controls. Another group...[Show more]
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