The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome
Butt, Alison J; Sergio, C Marcelo; Inman, Claire K; Anderson, Luke R; McNeil, Catriona M; Russell, Amanda; Nousch, Marco; Preiss, Thomas; Biankin, Andrew V; Sutherland, Robert L; Musgrove, Elizabeth A
Introduction: Estrogens play a pivotal role in the initiation and progression of breast cancer. The genes that mediate these processes are not fully defined, but potentially include the known mammary oncogene MYC. Characterization of estrogen-target genes may help to elucidate further the mechanisms of estrogen-induced mitogenesis and endocrine resistance.Methods: We used a transcript profiling approach to identify targets of estrogen and c-Myc in breast cancer cells. One previously...[Show more]
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