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IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4/IL-13 Following HIV-1 Prime-Boost Immunization

Ravichandran, Jayashree; Jackson, Ronald; Trivedi, Shubhanshi; Ranasinghe, Charani


Although Th1 and Th2 cytokines can inhibit interleukin (IL)-17-secreting T cells, how these cells are regulated under different infectious conditions is still debated. Our previous studies have shown that vaccination of IL-4 and IL-13 gene knockout (KO) mice can induce high-avidity HIV KdGag<inf>197-205</inf>-specific CD8 T cells with better protective efficacy. In this study, when IL-13, IL-4, STAT6 KO, and wild-type BALB/c mice were prime-boost immunized with an HIV poxviral modality,...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Interferon and Cytokine Research
DOI: 10.1089/jir.2014.0078


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