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Complement activation in retinal degeneration

Rutar, Matthew; Natoli, Riccardo; Provis, Jan; Valter (Valter-Kocsi), Krisztina


Our aim is to investigate a common role of the complement system in the pathogenesis of retinal disease, by assessing the expression profile of complement component 3 (C3) in three mechanistically distinct models of retinal degeneration: light-damage, hyperoxia and the degenerative P23H-3 rodent strain. In the light damage model, young adult albino Sprague Dawley (SD) rats were exposed to 1,000 lx for a period of up to 24 h, where at specific time points during and after exposure, animals were...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Book chapter
DOI: 10.1007/978-1-4614-0631-0_5


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