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Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis

Shonhai, Addmore; Maier, Alex; Przyborski, Jude M; Blatch, Gregory L


Certain kinetoplastid (Leishmania spp. and Trypanosoma cruzi) and apicomplexan parasites (Plasmodium falciparum and Toxoplasma gondii) are capable of invading human cells as part of their pathology. These parasites appear to have evolved a relatively expanded or diverse complement of genes encoding molecular chaperones. The gene families encoding heat shock protein 90 (Hsp90) and heat shock protein 70 (Hsp70) chaperones show significant expansion and diversity (especially for Leishmania spp....[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Protein and Peptide Letters
DOI: 10.2174/092986611794475002


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