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Transient transmission of porcine endogenous retrovirus to fetal lambs after pig islet tissue xenotransplantation

Popp, Sarah; Mann, David; Milburn, Peter J; Gibbs, Adrian; McCullagh, Peter; Wilson, James Dennis; Tonjes, Ralf R.; Simeonovic, Charmaine

Description

Evidence for the in vivo transmission of porcine endogenous retrovirus (PERV) from porcine xenografts to various recipient animals has been inconsistent. To characterize the contribution of the host immune system to the potential for PERV transmission from pig islet tissue xenografts to host tissues, we examined two immunoincompetent animal models, thymectomizsed fetal lambs and NODscid mice. Pig proislets were grafted into fetal lambs or adult NODscid mice. Conventional, nested and real-time...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/52139
Source: Immunology and Cell Biology
DOI: 10.1038/sj.icb.7100028

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