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Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor

Bernabeu, M; Lopez, FJ; Ferrer, M; Martin-Jaular, L; Razaname, A; Corradin, G; Maier, Alex; del Portillo, HA; Fernandez-Becerra, C


The subcellular localization and function of variant subtelomeric multigene families in Plasmodium vivax remain vastly unknown. Among them, the vir superfamily is putatively involved in antigenic variation and in mediating adherence to endothelial receptors. In the absence of a continuous in vitro culture system for P. vivax, we have generated P. falciparum transgenic lines expressing VIR proteins to infer location and function. We chose three proteins pertaining to subfamilies A (VIR17), C...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Cellular Microbiology
DOI: 10.1111/j.1462-5822.2011.01726.x


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