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Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

Martin, Rowena; Marchetti, Rosa; Cowan, Anna; Howitt, Susan; Broer, Stefan; Kirk, Kiaran

Description

The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter (PfCRT), an integral membrane protein localized

dc.contributor.authorMartin, Rowena
dc.contributor.authorMarchetti, Rosa
dc.contributor.authorCowan, Anna
dc.contributor.authorHowitt, Susan
dc.contributor.authorBroer, Stefan
dc.contributor.authorKirk, Kiaran
dc.date.accessioned2015-12-10T22:20:52Z
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/1885/52123
dc.description.abstractThe emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter (PfCRT), an integral membrane protein localized
dc.publisherAmerican Association for the Advancement of Science
dc.sourceScience
dc.subjectKeywords: amantadine; amodiaquine; artemisinin; chloroquine; piperaquine; quinine; verapamil; digestive system disorder; disease resistance; disease transmission; gene expression; health care; malaria; membrane; mutation; protein; acidity; article; binding site; co
dc.titleChloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume325
dc.date.issued2009
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationu4325460xPUB239
local.type.statusPublished Version
local.contributor.affiliationMartin, Rowena, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMarchetti, Rosa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCowan, Anna, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHowitt, Susan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBroer, Stefan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage1680
local.bibliographicCitation.lastpage1682
local.identifier.doi10.1126/science.1175667
dc.date.updated2016-02-24T10:54:48Z
local.identifier.scopusID2-s2.0-70349524663
local.identifier.thomsonID000270131800043
CollectionsANU Research Publications

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