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Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

Lopaticki, Sash; Maier, Alex; Thompson, Jennifer; Wilson, Danny W; Tham, Wai-Hong; Triglia, Tony; Gout, Alex; Speed, Terence P; Beeson, James G; Healer, Julie; Cowman, A

Description

Plasmodium falciparum causes the most severe form of malaria in humans and invades erythrocytes using multiple ligand-receptor interactions. Two important protein families involved in erythrocyte binding are the erythrocyte binding-like (EBL) and the reticulocyte binding-like (RBL or P. falciparum Rh [PfRh]) proteins. We constructed P. falciparum lines lacking expression of EBL proteins by creating single and double knockouts of the corresponding genes for eba-175, eba-181, and eba-140 and show...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/52089
Source: Infection and Immunity
DOI: 10.1128/IAI.01021-10

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