miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
Swarbrick, Alexander; Woods, Susan L; Shaw, Alexander; Balakrishnan, Asha; Phua, Yuwei; Nguyen, Akira; Chanthery, Yvan; Lim, Lionel; Ashton, Lesley J; Judson, Robert L; Huskey, Noelle; Blelloch, Robert; Haber, Michelle; Norris, Murray D; Lengyel, Peter; Hackett, Christopher S; Preiss, Thomas; Chetcuti, Albert; Marcusson, Eric G; Weiss, William; L'Etoile, Noelle; Goga, Andrei
A drawback of electrical stimulation for muscle control is that large, fatigable motor units are preferentially recruited before smaller motor units by the lowest-intensity electrical cuff stimulation. This phenomenon limits therapeutic applications because it is precisely the opposite of the normal physiological (orderly) recruitment pattern; therefore, a mechanism to achieve orderly recruitment has been a long-sought goal in physiology, medicine and engineering. Here we demonstrate a...[Show more]
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