The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase: an essential enzyme in the γ-glutamyl cycle
The hypothetical protein C7orf24 has been implicated as a cancer marker with a potential role in cell proliferation. We have identified C7orf24 as γ-glutamyl cyclotransferase (GGCT) that catalyzes the formation of 5-oxoproline (pyroglutamic acid) from γ
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|Source:||Journal of Biological Chemistry|
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