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The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase: an essential enzyme in the γ-glutamyl cycle

Oakley, Aaron; Yamada, Tetsuo; Liu, Dan; Coggan, Marjorie; Clark, Alan; Board, Philip


The hypothetical protein C7orf24 has been implicated as a cancer marker with a potential role in cell proliferation. We have identified C7orf24 as γ-glutamyl cyclotransferase (GGCT) that catalyzes the formation of 5-oxoproline (pyroglutamic acid) from γ

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M803623200


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