Skip navigation
Skip navigation

mRNA isoform diversity can obscure detection of miRNA-mediated control of translation

Clancy, Jennifer; Wei, Grace H; Echner, N; Humphreys, David T; Beilharz, Traude H; Preiss, Thomas

Description

Reporter-based studies support inhibition of translation at the level of initiation as a substantial component of the miRNA mechanism, yet recent global analyses have suggested that they predominantly act through decreasing target mRNA stability. Cells commonly coexpress several processing isoforms of an mRNA, which may also differ in their regulatory untranslated regions (UTR). In particular, cancer cells are known to express high levels of short 3′ UTR isoforms that evade miRNA-mediated...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/51976
Source: RNA
DOI: 10.1261/rna.2567611

Download

File Description SizeFormat Image
01_Clancy_mRNA_isoform_diversity_can_2011.pdf765.2 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator