mRNA isoform diversity can obscure detection of miRNA-mediated control of translation
Reporter-based studies support inhibition of translation at the level of initiation as a substantial component of the miRNA mechanism, yet recent global analyses have suggested that they predominantly act through decreasing target mRNA stability. Cells commonly coexpress several processing isoforms of an mRNA, which may also differ in their regulatory untranslated regions (UTR). In particular, cancer cells are known to express high levels of short 3′ UTR isoforms that evade miRNA-mediated...[Show more]
|Collections||ANU Research Publications|
|01_Clancy_mRNA_isoform_diversity_can_2011.pdf||765.2 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.