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mRNA isoform diversity can obscure detection of miRNA-mediated control of translation

Clancy, Jennifer; Wei, Grace H; Echner, N; Humphreys, David T; Beilharz, Traude H; Preiss, Thomas


Reporter-based studies support inhibition of translation at the level of initiation as a substantial component of the miRNA mechanism, yet recent global analyses have suggested that they predominantly act through decreasing target mRNA stability. Cells commonly coexpress several processing isoforms of an mRNA, which may also differ in their regulatory untranslated regions (UTR). In particular, cancer cells are known to express high levels of short 3′ UTR isoforms that evade miRNA-mediated...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: RNA
DOI: 10.1261/rna.2567611


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