Skip navigation
Skip navigation

Synthesis and biological evaluation of some enantiomerically pure C8c-C15-monoseco analogues of the phenanthroquinolizidine-type alkaloids cryptopleurine and julandine

Sydnes, Magne; Bezos, Anna; Burns, Christopher; Kruszelnicki, Irma; Su, Stephen; Rae, A David; Willis, Anthony; Banwell, Martin; Parish, Christopher


A series of enantiomerically pure C8cC15 monoseco analogues, 2330, of the alkaloids cryptopleurine (1) and julandine (2) have been prepared using cinnamyl chloride 37 and (S)- or (R)-2-methylpiperidine as key building blocks. Two related compounds, 31 and 32, have also been synthesized. Each of these analogues has been subjected to various biological evaluations and most of them show dramatically reduced cytotoxicity compared with parent system 1. Nevertheless, they are potent anti-angiogenic...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH08190


File Description SizeFormat Image
01_Sydnes_Synthesis_and_biological_2008.pdf451.09 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator