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IL-4 and IL-13 receptors: Roles in imunity and powerful vaccine adjuvants

Ranasinghe, Charani; Trivedi, Shubhanshi; Wijesundara, Danushka; Jackson, Ronald


The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Cytokine and Growth Factor Reviews
DOI: 10.1016/j.cytogfr.2014.07.010


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