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Fixing DNA breaks during class switch recombination

Jolly, Christopher J; Cook, Adam; Manis, John P


Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20080356


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