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Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis

West, Nicholas P; Thomson, Scott; Triccas, James A; Medveczky, C; Ramshaw, Ian; Britton, Warwick


The development of effective anti-Tuberculosis (TB) vaccines is an important step towards improved control of TB in high burden countries. Subunit vaccines are advantageous in terms of safety, particularly in the context of high rates of HIV co-infection, but they must contain sufficient Mycobacterium tuberculosis antigens to stimulate immunity in genetically diverse human populations. We have used a novel approach to develop a synthetic scrambled antigen vaccine (TB-SAVINE), comprised of...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Vaccine
DOI: 10.1016/j.vaccine.2011.07.109


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