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Cubic membranes: a structure-based design for DNA uptake

Almsherqi, Zakaria; Hyde, Stephen; Ramachandran, Malarmathy; Deng, Yuru


Cubic membranes are soft three-dimensional crystals found within cell organelles in a variety of living systems, despite the aphorism of Fedorov: 'crystallization is death'. They consist of multi-bilayer lipid-protein stacks, folded onto anticlastic surfaces that resemble triply periodic minimal surfaces, forming highly swollen crystalline sponges. Although cubic membranes have been observed in numerous cell types and under different pathophysiological conditions, knowledge about the formation...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of the Royal Society. Interface
DOI: 10.1098/rsif.2007.1351


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