Distinct in vitro myelopoiesis is dependent on the self-renewal of hematopoietic progenitors

Abstract

Spleen and bone marrow (BM) have been shown to contain the progenitors of a novel dendritic-like antigen-presenting cell type (L-DC). These progenitors are also maintained in both long-term spleen cultures and co-cultures of spleen or BM over the stromal