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The Ectromelia Virus SPI-2 Protein Causes Lethal Mousepox by Preventing NK Cell Responses

Silva, Carolina; Tscharke, David; Lobigs, Mario; Koskinen, Aulikki; Wong, Yik Chun; Buller, R Mark; Mullbacher, Arno; Regner, Matthias


Ectromelia virus (ECTV) is a natural pathogen of mice that causes mousepox, and many of its genes have been implicated in the modulation of host immune responses. Serine protease inhibitor 2 (SPI-2) is one of these putative ECTV host response modifier proteins. SPI-2 is conserved across orthopoxviruses, but results defining its mechanism of action and in vivo function are lacking or contradictory. We studied the role of SPI-2 in mousepox by deleting the SPI-2 gene or its serine protease...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.00256-11


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