The Ectromelia Virus SPI-2 Protein Causes Lethal Mousepox by Preventing NK Cell Responses
Ectromelia virus (ECTV) is a natural pathogen of mice that causes mousepox, and many of its genes have been implicated in the modulation of host immune responses. Serine protease inhibitor 2 (SPI-2) is one of these putative ECTV host response modifier proteins. SPI-2 is conserved across orthopoxviruses, but results defining its mechanism of action and in vivo function are lacking or contradictory. We studied the role of SPI-2 in mousepox by deleting the SPI-2 gene or its serine protease...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Virology|
|01_Silva_The_Ectromelia_Virus_SPI-2_2011.pdf||4.04 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.