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Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

Wunnapuk, Klintean; Medley, Gregory A; Liu, Xin; Grice, Jeffrey E; Jayasinghe, Sudheera; Gawarammana, Indika; Buckley, Nicholas; Roberts, M


Simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been developed and validated for quantification of paraquat (PQ) in plasma and urine. Plasma and urine sample preparation were carried out by one-step protein precipitation using cold acetonitrile (-20 to -10 °C). After centrifugation, an aliquot of 10 μL of supernatant was injected into a Kinetex™ hydrophilic interaction chromatography (HILIC) column with a KrudKatcher™ Ultra in-line filter....[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Chromatography B
DOI: 10.1016/j.jchromb.2011.09.008


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