O'Neill, Helen; Griffiths, Kristin; Periasamy, Pravin; Hinton, Rebecca; Hey, Ying Ying; Petvises, Sawang; Tan, Jonathan
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these...[Show more]
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