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Stimulation of the amino acid transport SLC6A19 by JAK2

Bhavsar, Shefalee; Hosseinzadeh, Zohreh; Merches, Katja; Gu, Shuchen; Broer, Stefan; Lang, Florian

Description

JAK2 (Janus kinase-2) is expressed in a wide variety of cells including tumor cells and contributes to the proliferation and survival of those cells. The gain of function mutationV617FJAK2 mutant is found in the majority of myeloproliferative diseases. Cell proliferation depends on the availability of amino acids. Concentrative cellular amino acid uptake is in part accomplished by Na+ coupled amino acid transport through SLC6A19 (B(0)AT). The present study thus explored whether JAK2 activates...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/51549
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2011.09.074

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