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An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

Eri, RD; Adams, RJ; Tran, TV; Tong, H; Das, I; Roche, DK; Oancea, I; Png, Chin Wen; Jeffery, PL; Radford-Smith, Graham L; Cook, Matthew; Florin, Timothy H.J.; McGuckin, Michael A.


We recently characterized Winnie mice carrying a missense mutation in Muc2, leading to severe endoplasmic reticulum stress in intestinal goblet cells and spontaneous colitis. In this study, we characterized the immune responses due to this intestinal epithelial dysfunction. In Winnie, there was a fourfold increase in activated dendritic cells (DCs; CD11c+ major histocompatibility complex (MHC) class II hi) in the colonic lamina propria accompanied by decreased colonic secretion of an inhibitor...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Mucosal Immunology
DOI: 10.1038/mi.2010.74


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