An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
-
Altmetric Citations
Eri, RD; Adams, RJ; Tran, TV; Tong, H; Das, I; Roche, DK; Oancea, I; Png, Chin Wen; Jeffery, PL; Radford-Smith, Graham L; Cook, Matthew; Florin, Timothy H.J.; McGuckin, Michael A.
Description
We recently characterized Winnie mice carrying a missense mutation in Muc2, leading to severe endoplasmic reticulum stress in intestinal goblet cells and spontaneous colitis. In this study, we characterized the immune responses due to this intestinal epithelial dysfunction. In Winnie, there was a fourfold increase in activated dendritic cells (DCs; CD11c+ major histocompatibility complex (MHC) class II hi) in the colonic lamina propria accompanied by decreased colonic secretion of an inhibitor...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/51534 |
Source: | Mucosal Immunology |
DOI: | 10.1038/mi.2010.74 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Eri_An_intestinal_epithelial_2010.pdf | 703.2 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 19 May 2020/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator