Skip navigation
Skip navigation

An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

Eri, RD; Adams, RJ; Tran, TV; Tong, H; Das, I; Roche, DK; Oancea, I; Png, Chin Wen; Jeffery, PL; Radford-Smith, Graham L; Cook, Matthew; Florin, Timothy H.J.; McGuckin, Michael A.


We recently characterized Winnie mice carrying a missense mutation in Muc2, leading to severe endoplasmic reticulum stress in intestinal goblet cells and spontaneous colitis. In this study, we characterized the immune responses due to this intestinal epithelial dysfunction. In Winnie, there was a fourfold increase in activated dendritic cells (DCs; CD11c+ major histocompatibility complex (MHC) class II hi) in the colonic lamina propria accompanied by decreased colonic secretion of an inhibitor...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Mucosal Immunology
DOI: 10.1038/mi.2010.74


File Description SizeFormat Image
01_Eri_An_intestinal_epithelial_2010.pdf703.2 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator