Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay
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McRobb, Lucinda; Handelsman, David J; Kazlauskas, Rymantas; Wilkinson, Shane M; McLeod, Malcolm; Heather, Alison K
Description
The recent identification of tetrahydrogestrinone (THG), a non-marketed designer androgen used for sports doping but previously undetectable by established mass spectrometry-based urine drug screens, and its production by a facile chemical modification of gestrinone has raised concerns about the risks of developing designer androgens from numerous marketed progestins. We therefore have used yeast-based in vitro androgen and progesterone bioassays to conduct a structure-activity study assessing...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/51524 |
Source: | Journal of Steroid Biochemistry and Molecular Biology |
DOI: | 10.1016/j.jsbmb.2007.10.008 |
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01_McRobb_Structure-activity_2008.pdf | 531.65 kB | Adobe PDF | Request a copy |
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