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Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay

McRobb, Lucinda; Handelsman, David J; Kazlauskas, Rymantas; Wilkinson, Shane M; McLeod, Malcolm; Heather, Alison K


The recent identification of tetrahydrogestrinone (THG), a non-marketed designer androgen used for sports doping but previously undetectable by established mass spectrometry-based urine drug screens, and its production by a facile chemical modification of gestrinone has raised concerns about the risks of developing designer androgens from numerous marketed progestins. We therefore have used yeast-based in vitro androgen and progesterone bioassays to conduct a structure-activity study assessing...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Steroid Biochemistry and Molecular Biology
DOI: 10.1016/j.jsbmb.2007.10.008


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