Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay
The recent identification of tetrahydrogestrinone (THG), a non-marketed designer androgen used for sports doping but previously undetectable by established mass spectrometry-based urine drug screens, and its production by a facile chemical modification of gestrinone has raised concerns about the risks of developing designer androgens from numerous marketed progestins. We therefore have used yeast-based in vitro androgen and progesterone bioassays to conduct a structure-activity study assessing...[Show more]
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|Source:||Journal of Steroid Biochemistry and Molecular Biology|
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