Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond
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SUMMARY This is a personal account of how tumour necrosis factor (TNF) the prototype of a group of host-origin mediators, often known as pro-inflammatory cytokines, came into parasitology, and was subsequently realised to be central to the pathogenesis of most disease pathology. This contribution summarizes an example of how a curiosity-driven outsider, with initially no intention of heading this way, and no relevant experience, and with no more than the simplest of plans but an ambition to...[Show more]
dc.contributor.author | Clark, Ian A | |
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dc.date.accessioned | 2015-12-10T22:18:37Z | |
dc.identifier.issn | 0031-1820 | |
dc.identifier.uri | http://hdl.handle.net/1885/51493 | |
dc.description.abstract | SUMMARY This is a personal account of how tumour necrosis factor (TNF) the prototype of a group of host-origin mediators, often known as pro-inflammatory cytokines, came into parasitology, and was subsequently realised to be central to the pathogenesis of most disease pathology. This contribution summarizes an example of how a curiosity-driven outsider, with initially no intention of heading this way, and no relevant experience, and with no more than the simplest of plans but an ambition to read as widely as it takes, and (most importantly) allowed to follow his head, can be what is required to give fresh insight into understanding a disease. It also gives the author's views on aspects of how the field of malaria disease pathogenesis seems to be developing. The hope is to inspire another generation to follow a similarly original course. | |
dc.publisher | Cambridge University Press | |
dc.source | Parasitology | |
dc.subject | Keywords: BCG vaccine; endotoxin; gamma interferon; malaria vaccine; recombinant tumor necrosis factor; tuberculin; tumor necrosis factor alpha; Babesia; babesiosis; biogenesis; brain malaria; brain mitochondrion; brain protection; disease course; drug mechanism; e Babesia; Disease; Malaria; Mitochondria; TNF; Vaccine | |
dc.title | Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 136 | |
dc.date.issued | 2009 | |
local.identifier.absfor | 060502 - Infectious Agents | |
local.identifier.ariespublication | u4325460xPUB225 | |
local.type.status | Published Version | |
local.contributor.affiliation | Clark, Ian A, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 1457 | |
local.bibliographicCitation.lastpage | 1468 | |
local.identifier.doi | 10.1017/S0031182009006088 | |
dc.date.updated | 2016-02-24T10:54:41Z | |
local.identifier.scopusID | 2-s2.0-70350574196 | |
Collections | ANU Research Publications |
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