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Fc-Disabled Anti-Mouse CD40L Antibodies Retain Efficacy in Promoting Transplantation Tolerance

Daley, Stephen; Cobbold, Stephen P; Waldmann, Hermann


CD40L antibodies have proven to be powerful immunosuppressive agents in nonhuman primates but unfortunately perturb blood coagulation. Neither the therapeutic nor the prothrombotic mechanism of anti-CD40L is defined sufficiently to determine whether these effects can be uncoupled. Recent evidence suggests that the Fc region of anti-CD40L antibodies interacting with Fc receptors plays an important role in stabilizing platelet aggregates. An Fc-disabled, aglycosylated anti-CD40L heavy chain...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: American Journal of Transplantation
DOI: 10.1111/j.1600-6143.2008.02382.x


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