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Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-nangustine

Kokas, Okanya; Banwell, Martin; Willis, Anthony


The synthesis of (+)-nangustine [(+)-2] has been achieved, for the first time, using the enantiomerically pure cis-1,2-dihydrocatechol 3 as starting material. The latter compound is available, in multi-gram quantities, through a whole-cell-mediated biotransformation of chlorobenzene using genetically engineered organisms that over-express the responsible enzyme, namely toluene dioxygenase. Since the enantiomer of compound 3 is available by related means, the present work also represents a...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Tetrahedron
DOI: 10.1016/j.tet.2008.04.070


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