Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-nangustine
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Kokas, Okanya; Banwell, Martin; Willis, Anthony
Description
The synthesis of (+)-nangustine [(+)-2] has been achieved, for the first time, using the enantiomerically pure cis-1,2-dihydrocatechol 3 as starting material. The latter compound is available, in multi-gram quantities, through a whole-cell-mediated biotransformation of chlorobenzene using genetically engineered organisms that over-express the responsible enzyme, namely toluene dioxygenase. Since the enantiomer of compound 3 is available by related means, the present work also represents a...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/51480 |
Source: | Tetrahedron |
DOI: | 10.1016/j.tet.2008.04.070 |
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