Pouliquin, Pierre; Pace, Suzy M; Curtis, Suzanne; Harvey, Peta; Gallant, Esther; Zorzato, Francesco; Casarotto, Marco; Dulhunty, Angela
We have determined the structure of a domain peptide corresponding to the extreme 19 C-terminal residues of the ryanodine receptor Ca2+ release channel. We examined functional interactions between the peptide and the channel, in the absence and in the presence of the regulatory protein Homer. The peptide was partly α-helical and structurally homologous to the C-terminal end of the T1 domain of voltage-gated K+ channels. The peptide (0.1-10 μM) inhibited skeletal ryanodine receptor channels when...[Show more]
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